Invited Speaker 5th Modern Solid Phase Peptide Synthesis Symposium 2015

• Chemical synthesis of homogeneous glycoproteins and insight into the relationship between glycosylation pattern and biological activity - Yasuhiro Kajihara
• Synthesis of [lys8]-oxytocin dendrimers that maintain potency and structure and inhibit visceral nociceptive responses - Paul Alewood

• New methods for peptide cyclization and acetylation - Assaf Friedler
• Rationally designed fluorescent probes of the antimicrobial cyclic-lipopeptide, polymyxin B - Kade D Roberts
• Aqueous microwave-assisted solid-phase peptide synthesis using Fmoc strategy - Keiko Hojo
• Problem of aspartimide formation in microwave assisted Fmoc solid phase peptide synthesis - Taj Muhammad
• Characterization of starting resins used for SPPS - Daniel Samson

• Ultra rapid flow based peptide synthesis - Brad Pentelute
• Total synthesis of YM-280193, an antiplatelet cyclic depsipeptide - Harveen Kaur
• Dicarba a–conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABA_B receptors  - Alessia Belgi
• Studies toward the total synthesis of Skyllamycins A-C - Andrew M. Giltrap
• Downsizing disulfide-rich peptides - Richard J Clark

• Mitocryptides: Structure-activity relationships of a novel family of neutrophil-activating peptides - Hidehito Mukai
• Peptide prodrugs targeting the SH2 domain of p85 block PI3K trafficking and signaling - John S McMurray
• Targeting of the GPCR, relaxin family peptide receptor 1 (RXFP1) - M. Akhter Hossain
• Metabolically-stable somatostatin analogs having a complex type disialyl-undecasaccharide with high affinity to all the receptor subtypes - Yuji Nishiuchi
• Intracellular target-specific activities of proteomimetic bioportides - John Howl

• N-Sulfanyethylanilide peptide as a crypto thioester for protein chemical synthesis - Akira Otaka
• New ligation technologies for the rapid assembly of modified proteins as therapeutic leads - Richard J. Payne
• Peptide ligation via prior capture and intramolecular acyl transfer - Chuan Fa Liu
• Peptide-thioesters in chemistry and biology: From total chemical protein synthesis to peptide ligases - Thomas Durek

• Fmoc-based solid phase synthesis strategies to access biosynthetic intermediates of glycopeptide antibiotics that enable enzymatic bioconjugation - Max J. Cryle
• Effect of unnatural amino acids and lipid moieties on the activity of antimicrobial peptides - Neil M O'Brien-Simpson
• Potent proline-rich antimicrobial peptides against nosocomial Gram-negative bacteria - Li Wenyi
• Lipopeptide-based mucosal vaccine candidates against Group A Streptococcus - Mariusz Skwarczynski
• Biodistribution of proline-rich antimicrobial peptides in mice using different administration routes - Ralf Hoffmann

Sponsored by:

• Optimizing solid phase peptide synthesis at elevated temperature - Jonathan M. Collins
• Non-radioactive labeling of peptide drugs - Laszlo Otvos
• A novel bis-linker strategy for the synthesis of multiple polypeptide chains on single solid support - Nitin Patil
• A safety catch linker approach enabling high throughput synthesis of peptide mimetcs librarys - Andreas Brust
• Direct encoding/decoding of on-bead peptides using SERS barcoding system - Yoon-Sik Lee

• Diaminodiacid bridges to improve folding and tune the bioactivity of disulfide-rich peptides - Lei Liu
• Making easy the synthesis of the so-called “difficult peptides” - Fernando Albericio